responsive gene discovery problem

or objective of a biological investigation through an experiment

ntify genes with some desired functions. When a species or an

has experienced a stress and some phenotypic phenomenon has

erved, it is desirable to study which genes have responded to the

gene which shows a significant response to a stress in an

on with a phenotypical phenomenon or a phenomenon change is

esponsive gene [Alves, et al., 2016]. Responsive gene discovery

ss-related experiment is called a genotype-phenotype mapping

Bassel, 2019; Bolker, 2019; Koch, 2019; Lian, et al., 2019;

i, et al., 2020; Kowalko, 2020; Morris, et al., 2020].

main objective of a genotype-phenotype mapping process is to

either a qualitative or quantitative associative model. Based on

odel, it is aimed to discover and thus describe the dependency

hip between the genotype data and the phenotype data in an

nt. Afterwards, either the interpretation of the existing

na or the prediction of future events is followed.

ponsive gene is also called an essential gene or a differentially

d gene depending on an experiment. Normally, the proportion of

ve genes is small in most biological experiments. This thus

a traditional basis for simplifying, but not completely ignoring

lexity of a biological system to some focal points of interest [Lai,

08; Chen, et al., 2011; Zong, et al., 2013 ; Alves, et al., 2016; Liu,

16; Antolovic, et al., 2019; Sidorenko, et al., 2019; Trolet, et al.,

are mainly two types of approaches for the genotype-phenotype

study. The two types depend on how an experiment has been

out. Suppose a phenotypical phenomenon (change) within a

l system has been observed and the corresponding activity

of all genes of the species have been recorded. What a researcher

do next is to find which genes are the responsive genes. For

suppose the bacterial growth has been observed in a transposon